Cerebral amyloid in mice with Creutzfeldt-Jakob disease is influenced by the strain of the infectious agent

Tetsuyuki Kitamoto, Ruriko Yi, Shirou Mohri, Jun Tateishi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We examined Fukuoka-1 and Fukuoka-2 mouse-adapted Creutzfeldt-Jakob disease strains. Mice infected with the Fukuoka-2 strain have a higher incidence of kuru plaques, a higher concentration of proteinase-resistant prion protein, and a higher infectivity titer than do mice with the Fukuoka-1 strain. Thus, it must be kept in mind that there is a difference in the strain of the infectious agent in murine Creutzfeldt-Jakob disease.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalBrain research
Volume508
Issue number1
DOIs
Publication statusPublished - 1990 Jan 29
Externally publishedYes

Keywords

  • Agent strain
  • Amyloid
  • Creutzfeldt-Jakob disease
  • Infectious agent
  • Mouse
  • Prion protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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