Cerebellin in the cerebellum in spinocerebellar degeneration

Y. Mizuno, K. Takahashi, Kazuhito Totsune, M. Ohneda, H. Konno, O. Murakami, F. Satoh, M. Sone, S. Takase, Y. Itoyama, T. Mori

Research output: Contribution to journalArticlepeer-review

Abstract

To clarify the possible pathophysiological role of cerebellin in spinocerebellar degeneration, immunoreactive cerebellin was measured in the postmortem brain of 4 patients with spinocerebellar degeneration and 4 controls. Three other representative neuropeptides, corticotropin releasing hormone (CRH), neuropeptide Y and somatostatin, were also measured. Significant decreases in the concentration of immunoreactive cerebellin and immunoreactive CRH were found in the cerebellar hemisphere in spinocerebellar degeneration, suggesting an important pathophysiological role of cerebellin and CRH in this group of diseases. No such decreases were found in neuropeptide Y or somatostatin.

Original languageEnglish
Pages (from-to)1069-1074
Number of pages6
JournalBrain and Nerve
Volume47
Issue number11
Publication statusPublished - 1995 Jan 1

Keywords

  • cerebellin
  • corticotropin- releasing hormone cerebellum
  • neuropeptide
  • spinocerebellardegenerations

ASJC Scopus subject areas

  • Neuroscience(all)

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