CeO 2-catalyzed one-pot selective synthesis of N-alkyl amides from nitriles, amines and water

Masazumi Tamura, Takuya Tonomura, Ken Ichi Shimizu, Atsushi Satsuma

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Among 13 kinds of metal oxides, ceria (CeO 2) shows the highest catalytic activity for one-pot selective synthesis of the secondary amide from 2-cyanopyridine and n-octylamine as a test reaction. CeO 2 acts as a reusable heterogeneous catalyst, and it is effective for the secondary amide formation from various nitriles and amines in high yields (73% to >99%). Pharmacologically important products such as heteroaromatic N-alky amides and morpholine amide are effectively synthesized, indicating that CeO 2 can be a practically useful catalyst. A proposed mechanism includes (1) hydration of nitrile to the primary amide and (2) transamidation of the primary amide with amine as the rate-limiting step. This reaction mechanism provides a reason why the present catalytic system gives high selectivity.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalApplied Catalysis A: General
Publication statusPublished - 2012 Feb 29
Externally publishedYes


  • Amides
  • Cerium oxide
  • One-pot synthesis

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology


Dive into the research topics of 'CeO <sub>2</sub>-catalyzed one-pot selective synthesis of N-alkyl amides from nitriles, amines and water'. Together they form a unique fingerprint.

Cite this