Centromere structures highlighted by the 100%-complete Cyanidioschyzon merolae genome

Shinichiro Maruyama, Motomichi Matsuzaki, Haruko Kuroiwa, Shin Ya Miyagishima, Kan Tanaka, Tsuneyoshi Kuroiwa, Hisayoshi Nozaki

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Centromere dynamics are largely unknown in lower plants (algae). We have recently identified the centromere-specific histone H3 variant (CENH3) and clarified the dynamic centromere rearrangement at mitosis in the primitive red alga Cyanidioschyzon merolae. We also showed that the CENH3-containing nucleosomes constituted the kinetochore closely interacting with the nuclear envelope. CENH3 visualization during the whole cell cycle suggests that C. merolae centromeres are monocentric and confined to specific loci. We completed 100% no-gap telomereto-telomere sequencing of the C. merolae genome. Interestingly, a single A+T-rich region has been identified on each fully sequenced chromosome. No centromere-like A+T-rich repetitive sequence have been found within these regions, implying that the C. merolae centromeres may be 'point' centromeres, or be comprised of non-repetitive heterogeneous DNA sequences.

Original languageEnglish
Pages (from-to)140-141
Number of pages2
JournalPlant Signaling and Behavior
Volume3
Issue number2
DOIs
Publication statusPublished - 2008 Feb

Keywords

  • Centromere
  • Chromosome structure
  • Complete nuclear genome
  • Cyanidioschyzon
  • Repetitive DNA

ASJC Scopus subject areas

  • Plant Science

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