Central noradrenergic pathways are not involved in the pressor response to intracerebroventricular substance P

Emilio Badoer, Hartmut Würth, Fatimunnisa Qadri, Keiichi Itoi, Thomas Unger

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Intracerebroventricular (i.c.v.) pretreatment of Wistar rats with the catecholaminergic neurotoxin, 6-hydroxydopamine, significantly reduced noradrenaline in the pons/medulla (by 73%) and almost abolished the noradrenaline levels in the spinal cord (by 89%) The pressor response of these animals to i.c.v. angiotensin II (ANGII, 10 ng) was significantly attenuated. In contrast, there was no significant effect on the pressor response to i.c.v. substance P (SP, 100 ng). The results provide evidence that different central pathways mediate the pressor response to ANGII and SP.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalEuropean Journal of Pharmacology
Volume154
Issue number1
DOIs
Publication statusPublished - 1988 Sep 1
Externally publishedYes

Keywords

  • (Intracerebroventricular administration)
  • Angiotensin II
  • Brain
  • Noradrenaline
  • Substance P

ASJC Scopus subject areas

  • Pharmacology

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