Cellular uptake behavior of fluorescein: Intercalated layered double hydroxide

Miyuki Tanaka, Sumio Aisawa, Hidetoshi Hirahara, Eiichi Narita, Shu Yin, Tsugio Sato

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    In order to define the ability of layered double hydroxide (LDH) as materials for drug delivery, fluorescein (Fluo) anion intercalated LDH (Fluo/LDH) was synthesized by hydrothermal treatment and observed the cellular uptake of the Fluo/LDH for mammalian cell (L929). The synthesized Fluo/LDH showed a LDH structure, high fluorescence and low cytotoxicity. According to the fluorescence, confocal and TEM images of cells, the Fluo/LDH seemed to be internalized into the L929 cell by cellular endocytosis and dissolved inside the cell to exhibit the fluorescence of cellular cytoplasm.

    Original languageEnglish
    Article number1260003
    JournalFunctional Materials Letters
    Issue number2
    Publication statusPublished - 2012 Jun


    • Layered double hydroxide
    • cellular uptake
    • fluorescein

    ASJC Scopus subject areas

    • Materials Science(all)


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