Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Kazuo Fujihara, Yasuto Itoyama, Feng Yu, Chiharu Kubo, Ikuo Goto

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalJournal of the neurological sciences
Volume105
Issue number1
DOIs
Publication statusPublished - 1991 Sep

Keywords

  • Cell-mediated cytotoxicity
  • Cytotoxic T lymphocyte activity
  • HTLV-I associated myelopathy
  • Immune surveillance
  • Natural killer cell activity
  • Tropical spastic paraparesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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