Cellular colocalization of calcium/calmodulin-dependent protein kinase II and calcineurin in the rat cerebral cortex and hippocampus

Satoshi Goto, Shinji Nagahiro, Kojiro Korematsu, Yukitaka Ushio, Kohji Fukunaga, Eishichi Miyamoto, Walter Hofer

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

An immunoperoxidase technique was used to locate multifunctional Ca2+/calmodulin-regulated protein phosphatase (calcineurin) and kinase (CaM-kinase II) in the rat cerebral cortex and hippocampus. Immunoreactivities for both enzymes were highly concentrated in the brain regions, where pyramidal-shaped neurons revealed strong immunoreactivities in their perikarya and dendrites. Serial thin section analysis using the polyethylene glycol embedding procedure disclosed that the cellular distribution of calcineurin immunolabelling in the cerebral cortex and hippocampus was similar to that of CaM-kinase II. The present findings suggest that the phosphatase and kinase may interact with each other in such neuronal subsets.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalNeuroscience Letters
Volume149
Issue number2
DOIs
Publication statusPublished - 1993 Jan 12
Externally publishedYes

Keywords

  • Calcineurin
  • Cerebral cortex
  • Hippocampus
  • Immunocytochemistry
  • Type II Ca/calmodulin-dependent protein kinase

ASJC Scopus subject areas

  • Neuroscience(all)

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