Cell sheet fabrication using RGD peptide-coupled alginate hydrogels fabricated by an electrodeposition method

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Abstract

A novel and simple method for constructing cell sheets is described in which culture surfaces were modified with RGD peptide-coupled alginate hydrogels using an electrodeposition method. Cells were cultured on the hydrogels to form a contiguous cell sheet-like structure. Then, the hydrogels were dissolved by addition of an EDTA solution and the cell sheets rapidly detached from the surface. This is the first report of the fabrication of cell sheets on RGD peptide-coupled alginate hydrogels using an electrodeposition method. We believe the technique is useful for cell sheet engineering.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
JournalChemistry Letters
Volume46
Issue number4
DOIs
Publication statusPublished - 2017

Keywords

  • Calcium-alginate hydrogel
  • Cell sheet
  • Electrochemistry

ASJC Scopus subject areas

  • Chemistry(all)

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