Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes

Hiroaki Matsumoto, Shotaro Yoshida, Yuya Morimoto, Nobuhito Mori, Daniela Serien, Shoji Takeuchi

Research output: Contribution to journalConference article

Abstract

We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces of cardiomyocytes. We believe that this method is a useful tool to study the biomechanics of cardiomyocytes.

Original languageEnglish
Article number7051024
Pages (from-to)589-592
Number of pages4
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2015-February
Issue numberFebruary
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes
Event2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal
Duration: 2015 Jan 182015 Jan 22

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Fingerprint Dive into the research topics of 'Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes'. Together they form a unique fingerprint.

  • Cite this