Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes

Hiroaki Matsumoto; Shotaro Yoshida; Yuya Morimoto; Nobuhito Mori; Daniela Serien; Shoji Takeuchi

doi:10.1109/MEMSYS.2015.7051024

Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes

Hiroaki Matsumoto, Shotaro Yoshida, Yuya Morimoto, Nobuhito Mori, Daniela Serien, Shoji Takeuchi

Research output: Contribution to journal › Conference article › peer-review

Abstract

We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces of cardiomyocytes. We believe that this method is a useful tool to study the biomechanics of cardiomyocytes.

Original language	English
Article number	7051024
Pages (from-to)	589-592
Number of pages	4
Journal	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2015-February
Issue number	February
DOIs	https://doi.org/10.1109/MEMSYS.2015.7051024
Publication status	Published - 2015 Jan 1
Externally published	Yes
Event	2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal Duration: 2015 Jan 18 → 2015 Jan 22

ASJC Scopus subject areas

Electrical and Electronic Engineering
Mechanical Engineering
Condensed Matter Physics
Electronic, Optical and Magnetic Materials

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10.1109/MEMSYS.2015.7051024

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Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes. / Matsumoto, Hiroaki; Yoshida, Shotaro; Morimoto, Yuya; Mori, Nobuhito; Serien, Daniela; Takeuchi, Shoji.

In: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Vol. 2015-February, No. February, 7051024, 01.01.2015, p. 589-592.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces of cardiomyocytes. We believe that this method is a useful tool to study the biomechanics of cardiomyocytes.",

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AU - Yoshida, Shotaro

AU - Morimoto, Yuya

AU - Mori, Nobuhito

AU - Serien, Daniela

AU - Takeuchi, Shoji

PY - 2015/1/1

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N2 - We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces of cardiomyocytes. We believe that this method is a useful tool to study the biomechanics of cardiomyocytes.

AB - We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces of cardiomyocytes. We believe that this method is a useful tool to study the biomechanics of cardiomyocytes.

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JO - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

JF - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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Cell-laden hinged microplates for measuring the contractile forces of cardiomyocytes

Abstract

ASJC Scopus subject areas

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