Cell fate polarization in ascidian mesenchyme/muscle precursors by directed FGF signaling and role for an additional ectodermal FGF antagonizing signal in notochord/nerve cord precursors

Gil Jung Kim, Gaku Kumano, Hiroki Nishida

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Asymmetric cell division plays a fundamental role in generating various types of embryonic cell. In ascidian embryos, asymmetric cell divisions occur in the vegetal hemisphere in a manner similar to those found in Caenorhabditis elegans. Early divisions in embryos of both species involve inductive events on a single mother cell that result in production of daughters with different cell fates. Here we show in the ascidian Halocynthia roretzi that polarity of muscle/mesenchyme mother precursors is determined solely by the direction from which the FGF9/16/ 20 signal is presented, a role similar to that of Wnt signaling in the EMS and T cell divisions in C. elegans. However, polarity of nerve cord/ notochord mother precursors is determined by possible antagonistic action between the FGF signal and a signal from anterior ectoderm, providing a new mechanism underlying asymmetric cell division. The ectoderm signal suppresses MAPK activation and expression of Hr-FoxA, which encodes an intrinsic competence factor for notochord induction, in the nerve cord lineage.

Original languageEnglish
Pages (from-to)1509-1518
Number of pages10
JournalDevelopment
Volume134
Issue number8
DOIs
Publication statusPublished - 2007 Apr
Externally publishedYes

Keywords

  • Ascidian embryo
  • Asymmetric cell division
  • Embryonic induction
  • FGF
  • FoxA
  • Mesenchyme
  • Notochord

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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