Cell-container prepared with cytocompatible phospholipid polymers for cell and tissue engineering

Tomohiro Konno, Kazuhiko Ishihara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We propose a novel polymeric hydrogel system as a cell container that can encapsulate cells in the polymer networks reversibly. A phospholipid polymer bearing 2-metha- cryloyloxyethyl phosphorylcholine units and p-vinylphenyl- boronic acid (PMBV) was synthesized to form a covalently cross-linking hydrogel with a polymer having multivalent hydroxyl groups such as poly (vinyl alcohol) (PVA). The hydrogel was formed not only in water but also even in the biological medium. However it was dissociated by addition of low molecular weight divalent hydroxyl compounds such as glucose. After fibroblast cells were added to PMBV solution and mixed with PVA, the cells were immobilized into the hydrogel. After dissociation of the hydrogel, the cells were adhered and proliferated as usual on a conventional cell culture plate. That is, the hydrogel system is useful to maintain the cells as a cell container.

Original languageEnglish
Title of host publicationPolymers for Biomedical Applications
PublisherAmerican Chemical Society
Pages336-345
Number of pages10
ISBN (Print)9780841239661
DOIs
Publication statusPublished - 2008 Mar 28
Externally publishedYes

Publication series

NameACS Symposium Series
Volume977
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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