Cell based therapy for COPD

Hiroshi Kubo

Research output: Contribution to journalReview articlepeer-review

Abstract

To develop a new cell based therapy for chronic obstructive pulmonary disease (COPD), we need to understand 1) the role of tissue-specific and bone marrow-derived stem cells, 2) extracellular matrix, and 3) growth factors. Recently, bronchioalveolar stem cells were identified in murine distal lungs. Impairment of these stem cells may cause improper lung repair after inflammation, resulting in pulmonary emphysema. Bone marrow-derived cells are necessary to repair injured lungs. However, the long term role of these cells is not understood yet. Although we need more careful analysis and additional experiments, growth factors, such as hepatocyte growth factor, are good candidates for the new cell based therapy for COPD. Lung was believed as a non-regenerative organ. Based on these recent reports about lung regeneration and stem cells, however, new strategies to treat COPD and a new point of view to understand the pathophysiology of COPD are rising.

Original languageEnglish
Pages (from-to)740-747
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Volume65
Issue number4
Publication statusPublished - 2007 Apr

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Cell based therapy for COPD'. Together they form a unique fingerprint.

Cite this