Cell adhesion and migration in response to nano-patterned surfaces formed by diblock copolymers

H. L. Khor, Y. J. Kuan, D. W. Hutmacher, K. Tamada, W. Knoll

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The cell adhesion and migration behavior on different nanopatterned surfaces was investigated to determine the effect of different nano-topography on cell function. The adsorption of extracellular matrix protein like fibronectin, on different nanopatterned surfaces, was performed by using immunofluorescence and contact angle measurements. The initial cell adhesion strength on the different substrates was studied by the use of laser tweezers. The live imaging of cell migration on the different substrates with cells transfected with EYFP-alpha-tubulin vector was studied. The initial cell culture on coated and plain mica strips demonstrated that hMSC displayed more of a polar morphology with long filopodium extensions on worm-like patterned substrates.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages383
Number of pages1
Publication statusPublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004 May 172004 May 21

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period04/5/1704/5/21

Keywords

  • Cell adhesion and migration
  • Nano-patterned surfaces
  • Self assembly polymers

ASJC Scopus subject areas

  • Engineering(all)

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