TY - JOUR
T1 - cDNA cloning and expression of human lactosylceramide synthase
AU - Takizawa, Minoru
AU - Nomura, Tomoko
AU - Wakisaka, Etsuji
AU - Yoshizuka, Naonobu
AU - Aoki, Junken
AU - Arai, Hiroyuki
AU - Inoue, Keizo
AU - Hattori, Michihiro
AU - Matsuo, Noboru
PY - 1999/5/18
Y1 - 1999/5/18
N2 - Lactosylceramide synthase is an enzyme that catalyzes the transfer of galactose from UDP-Gal to glucosylceramide, and thus participates in the biosynthesis of most glycolipids in mammals. We have isolated and sequenced the cDNA clone encoding human lactosylceramide synthase. The deduced amino acid sequence of the human lactosylceramide synthase showed 94.2% identity with rat lactosylceramide synthase. Northern blotting analysis revealed that lactosylceramide synthase mRNA was expressed in various tissues, with the highest level in brain and adrenal gland. Copyright (C) 1999.
AB - Lactosylceramide synthase is an enzyme that catalyzes the transfer of galactose from UDP-Gal to glucosylceramide, and thus participates in the biosynthesis of most glycolipids in mammals. We have isolated and sequenced the cDNA clone encoding human lactosylceramide synthase. The deduced amino acid sequence of the human lactosylceramide synthase showed 94.2% identity with rat lactosylceramide synthase. Northern blotting analysis revealed that lactosylceramide synthase mRNA was expressed in various tissues, with the highest level in brain and adrenal gland. Copyright (C) 1999.
KW - Lactosylceramide
KW - β1-4 Galactosyltransferase
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U2 - 10.1016/S1388-1981(99)00051-7
DO - 10.1016/S1388-1981(99)00051-7
M3 - Article
C2 - 10320813
AN - SCOPUS:0032906237
VL - 1438
SP - 301
EP - 304
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
SN - 1388-1981
IS - 2
ER -