CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

Yoji Yamashita; Isao Kasugai; Masami Sato; Nobuhiro Tanuma; Ikuro Sato; Miyuki Nomura; Katsumi Yamashita; Yukihiko Sonoda; Toshihiro Kumabe; Teiji Tominaga; Ryuichi Katakura; Hiroshi Shima

doi:10.1007/s11060-010-0147-3

CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

Yoji Yamashita, Isao Kasugai, Masami Sato, Nobuhiro Tanuma, Ikuro Sato, Miyuki Nomura, Katsumi Yamashita, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga, Ryuichi Katakura, Hiroshi Shima

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	Journal of Neuro-Oncology
Volume	100
Issue number	1
DOIs	https://doi.org/10.1007/s11060-010-0147-3
Publication status	Published - 2010 Oct

Keywords

CDC25A
Glioma
Ki-67
Protein phosphatase

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11060-010-0147-3

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title = "CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples",

abstract = "Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.",

keywords = "CDC25A, Glioma, Ki-67, Protein phosphatase",

author = "Yoji Yamashita and Isao Kasugai and Masami Sato and Nobuhiro Tanuma and Ikuro Sato and Miyuki Nomura and Katsumi Yamashita and Yukihiko Sonoda and Toshihiro Kumabe and Teiji Tominaga and Ryuichi Katakura and Hiroshi Shima",

note = "Funding Information: Acknowledgments This work was supported in part by Grants-in-aid for Scientific Research (C) to Y.Y. and H.S. and for Exploratory Research to R.K. provided by the Japan Society for the Promotion of Science.",

year = "2010",

month = oct,

doi = "10.1007/s11060-010-0147-3",

language = "English",

volume = "100",

pages = "43--49",

journal = "Journal of Neuro-Oncology",

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TY - JOUR

T1 - CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

AU - Yamashita, Yoji

AU - Kasugai, Isao

AU - Sato, Masami

AU - Tanuma, Nobuhiro

AU - Sato, Ikuro

AU - Nomura, Miyuki

AU - Yamashita, Katsumi

AU - Sonoda, Yukihiko

AU - Kumabe, Toshihiro

AU - Tominaga, Teiji

AU - Katakura, Ryuichi

AU - Shima, Hiroshi

N1 - Funding Information: Acknowledgments This work was supported in part by Grants-in-aid for Scientific Research (C) to Y.Y. and H.S. and for Exploratory Research to R.K. provided by the Japan Society for the Promotion of Science.

PY - 2010/10

Y1 - 2010/10

N2 - Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.

AB - Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.

KW - CDC25A

KW - Glioma

KW - Ki-67

KW - Protein phosphatase

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DO - 10.1007/s11060-010-0147-3

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AN - SCOPUS:79952191211

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CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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