CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

Yoji Yamashita, Isao Kasugai, Masami Sato, Nobuhiro Tanuma, Ikuro Sato, Miyuki Nomura, Katsumi Yamashita, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga, Ryuichi Katakura, Hiroshi Shima

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Neuro-Oncology
Volume100
Issue number1
DOIs
Publication statusPublished - 2010 Oct 1

Keywords

  • CDC25A
  • Glioma
  • Ki-67
  • Protein phosphatase

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Yamashita, Y., Kasugai, I., Sato, M., Tanuma, N., Sato, I., Nomura, M., Yamashita, K., Sonoda, Y., Kumabe, T., Tominaga, T., Katakura, R., & Shima, H. (2010). CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples. Journal of Neuro-Oncology, 100(1), 43-49. https://doi.org/10.1007/s11060-010-0147-3