CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: A clinicopathological analysis

Abul Faiz Kabir Uddin Ahmed, Haruo Ohtani, Masaki Nio, Nobuo Funaki, Satoru Shimaoka, Hiroshi Nagura, Ryoji Ohi

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12-79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow-up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Pathology
Volume193
Issue number3
DOIs
Publication statusPublished - 2001 Apr 2

Keywords

  • Biliary atresia
  • CD8
  • FasL
  • Granzyme B
  • Perforin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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