CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation

Mitsutaka Okuda; Jun Nomura; Hiroo Tateno; Junichi Kameoka; Takeshi Sasaki

doi:10.2169/internalmedicine.41.734

CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation

Mitsutaka Okuda, Jun Nomura, Hiroo Tateno, Junichi Kameoka, Takeshi Sasaki

MED - Office of Medical Education

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20 Citations (Scopus)

Abstract

A 63-year-old man presented with a perforation of the small intestine. A diagnosis of intestinal T-cell lymphoma (ITCL) was made from CD (cluster differentiation) 3 positivity and a rearrangement of T-cell receptor genes. The tumor also expressed CD56, which suggests it belongs to a rare subtype derived from activated cytotoxic intraepithelial T lymphocytes. Although the prognosis of ITCL has been considered to be very poor irrespective of CD56 positivity, complete remission was achieved in this case by high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) even after relapse. Auto-PBSCT in the earlier stage of the disease might improve the prognosis.

Original language	English
Pages (from-to)	734-737
Number of pages	4
Journal	Internal Medicine
Volume	41
Issue number	9
DOIs	https://doi.org/10.2169/internalmedicine.41.734
Publication status	Published - 2002 Sep 1

Keywords

Autologous peripheral blood stem cell transplantation
Jejunostomy
Natural killer cell-like
Perforation of jejunem

ASJC Scopus subject areas

Internal Medicine

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title = "CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation",

abstract = "A 63-year-old man presented with a perforation of the small intestine. A diagnosis of intestinal T-cell lymphoma (ITCL) was made from CD (cluster differentiation) 3 positivity and a rearrangement of T-cell receptor genes. The tumor also expressed CD56, which suggests it belongs to a rare subtype derived from activated cytotoxic intraepithelial T lymphocytes. Although the prognosis of ITCL has been considered to be very poor irrespective of CD56 positivity, complete remission was achieved in this case by high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) even after relapse. Auto-PBSCT in the earlier stage of the disease might improve the prognosis.",

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T1 - CD56 positive intestinal T-cell lymphoma

T2 - Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation

AU - Okuda, Mitsutaka

AU - Nomura, Jun

AU - Tateno, Hiroo

AU - Kameoka, Junichi

AU - Sasaki, Takeshi

PY - 2002/9/1

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N2 - A 63-year-old man presented with a perforation of the small intestine. A diagnosis of intestinal T-cell lymphoma (ITCL) was made from CD (cluster differentiation) 3 positivity and a rearrangement of T-cell receptor genes. The tumor also expressed CD56, which suggests it belongs to a rare subtype derived from activated cytotoxic intraepithelial T lymphocytes. Although the prognosis of ITCL has been considered to be very poor irrespective of CD56 positivity, complete remission was achieved in this case by high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) even after relapse. Auto-PBSCT in the earlier stage of the disease might improve the prognosis.

AB - A 63-year-old man presented with a perforation of the small intestine. A diagnosis of intestinal T-cell lymphoma (ITCL) was made from CD (cluster differentiation) 3 positivity and a rearrangement of T-cell receptor genes. The tumor also expressed CD56, which suggests it belongs to a rare subtype derived from activated cytotoxic intraepithelial T lymphocytes. Although the prognosis of ITCL has been considered to be very poor irrespective of CD56 positivity, complete remission was achieved in this case by high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) even after relapse. Auto-PBSCT in the earlier stage of the disease might improve the prognosis.

KW - Autologous peripheral blood stem cell transplantation

KW - Jejunostomy

KW - Natural killer cell-like

KW - Perforation of jejunem

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CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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