CD20-positive and CD4/CD8-double-negative peripheral T-cell lymphoma of spleen complicated with severe disseminated intravascular coagulation and enteropathy.

Satoshi Ichikawa, Shunsuke Hatta, Y. Saito, Jun Kimura, Keisuke Onishi, Mikio Matsuda, Ryo Ichinohasama, Hideo Harigae

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1 Citation (Scopus)

Abstract

A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3(+), CD4(-), CD8(-), T-cell receptor (TCR)αβ(+), and TCRγδ(-). After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20(+) PTCL-NOS. Although it is a rare disease entity, CD20(+) T-cell lymphoma can demonstrate aggressive clinical behavior.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalJournal of clinical and experimental hematopathology : JCEH
Volume52
Issue number2
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Medicine(all)

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