Cavitation assisted HIFU with phase-change nano droplet

Ken Ichi Kawabata, Rei Asami, Takashi Azuma, Hideki Yoshikawa, Shinichiro Umemura

Research output: Contribution to journalConference articlepeer-review

14 Citations (Scopus)


A preliminary study for therapeutic application of phase change nano droplet (PCND) in combination with low frequency ultrasound was performed. With gel phantom, it was found that the presence of PCND enhanced temperature elevation induced by 1.1-MHz ultrasound using albumin as the indicator of protein coagulation. Not like 2.2-MHz ultrasound, coagulation volume increased drastically as exposure time prolonged, suggesting the increase of numbers of bubbles which are responsible for the temperature elevation. Acoustic signal analysis showed that very violent cavitation is induced when PCND and 1.1-MHz ultrasound used. Animal experiments with mice tumor tissues were also performed and it was found that tissue erosion and necrosis were simultaneously generated. Results obtained showed the potential usefulness of PCND for mixed mechanism (HIFU & cavitation) therapy.

Original languageEnglish
Article number4803405
Pages (from-to)780-783
Number of pages4
JournalProceedings - IEEE Ultrasonics Symposium
Publication statusPublished - 2008 Dec 1
Event2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing, China
Duration: 2008 Nov 22008 Nov 5

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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