Catecholaminergic neurons in the diencephalon and basal ganglia of SIDS

Yuri Ozawa, Toshimasa Obonai, Masayuki Itoh, Yasuhiro Aoki, Masahito Funayama, Sachio Takashima

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32 Citations (Scopus)


The catecholaminergic systems of sudden infant death syndrome victims were examined in the diencephalon and basal ganglia, in addition to the midbrain, pons, and medulla oblongata, using the immuno-histochemical method involving tyrosine hydroxylase. A significant decrease in tyrosine hydroxylase immunoreactivity was demonstrated in the basal ganglia of sudden infant death syndrome victims between 2 to 12 months of age compared with age-matched control subjects. This change in the basal ganglia may be a secondary finding induced by chronic hypoxia or repeated ischemia in sudden infant death syndrome but suggests impairment of the development of the neuronal connection from the brainstem to the upper cardiorespiratory control in sudden infant death syndrome.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalPediatric Neurology
Issue number1
Publication statusPublished - 1999 Jul

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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