Catalytic method for the synthesis of C-N-linked BI(HETEROARYL)S using heteroaryl ethers and N -Benzoyl heteroarenes

Saori Tanii, Mieko Arisawa, Takaya Tougo, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

C-N-linked bi(heteroaryl)s are synthesized by a rhodium-catalyzed N-heteroarylation reaction of N-benzoyl heteroarenes including azoles/azolones, pyridones, cyclic ureas, and cyclic imides using heteroaryl aryl ethers. The reaction involves the covalent bond-exchange reaction of N-CO and HetAr-O bonds without using metal bases and exhibits a broad applicability, giving diverse C-N-linked bi(heteroaryl)s containing five- and six-membered heteroarenes. The N-heteroarylation of N-H azoles/azolones and pyridone proceeds at higher reaction temperatures.

Original languageEnglish
Pages (from-to)1756-1759
Number of pages4
JournalOrganic letters
Volume20
Issue number7
DOIs
Publication statusPublished - 2018 Apr 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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