Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN and stoichiometric amount of HCN

Nobuki Kato, Masato Suzuki, Motomu Kanai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Catalyst loading as low as 0.1mol% was achieved in the enantioselective Strecker reaction of ketoimines. Excellent enantioselectivity was obtained with a combined use of a catalytic amount of TMSCN and a stoichiometric amount of HCN as a reagent, and a chiral gadolinium complex as a catalyst.

Original languageEnglish
Pages (from-to)3153-3155
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number15
DOIs
Publication statusPublished - 2004 Apr 5
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Atom economy
  • Disubstituted amino acids
  • Ketoimines
  • Strecker reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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