Catalytic deprotonative functionalization of propargyl silyl ethers with imines

Hiroshi Naka, Daiki Koseki, Yoshinori Kondo

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A metal-free, catalytic C-H functionalization of propargyl silyl ethers with imines using the phosphazene base (t-Bu-P4 base) provides structurally defined multisubstituted pyrroles in modest to excellent yields under mild conditions. A one-pot, three-component reaction using silylated acetylenes, aldehydes, and imines is also presented.

Original languageEnglish
Pages (from-to)1901-1906
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume350
Issue number11-12
DOIs
Publication statusPublished - 2008 Aug 4

Keywords

  • Anionic reactions
  • C-C bond formation
  • Heterocycles
  • Metal-free conditions
  • Phosphazene bases

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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