Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs

Shigehisa Tanji, Harumi Aoyagi, Hayami Tabira, Itaru Sato, Kenso Soai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

(1S,2R)-N,N-Dialkylnorephedrines catalyze the enantioselective alkylation of various pyrazole-4-carbaldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazolylalkanols with up to 95% e.e. were obtained.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalHeterocycles
Volume53
Issue number2
Publication statusPublished - 2000 Feb 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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