Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs

Shigehisa Tanji; Harumi Aoyagi; Hayami Tabira; Itaru Sato; Kenso Soai

Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs

Shigehisa Tanji, Harumi Aoyagi, Hayami Tabira, Itaru Sato, Kenso Soai

SCI - Research and Analytical Center for Giant Molecules

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

(1S,2R)-N,N-Dialkylnorephedrines catalyze the enantioselective alkylation of various pyrazole-4-carbaldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazolylalkanols with up to 95% e.e. were obtained.

Original language	English
Pages (from-to)	381-386
Number of pages	6
Journal	Heterocycles
Volume	53
Issue number	2
Publication status	Published - 2000 Feb 1

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs",

abstract = "(1S,2R)-N,N-Dialkylnorephedrines catalyze the enantioselective alkylation of various pyrazole-4-carbaldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazolylalkanols with up to 95% e.e. were obtained.",

author = "Shigehisa Tanji and Harumi Aoyagi and Hayami Tabira and Itaru Sato and Kenso Soai",

year = "2000",

month = feb,

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language = "English",

volume = "53",

pages = "381--386",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs

AU - Tanji, Shigehisa

AU - Aoyagi, Harumi

AU - Tabira, Hayami

AU - Sato, Itaru

AU - Soai, Kenso

PY - 2000/2/1

Y1 - 2000/2/1

N2 - (1S,2R)-N,N-Dialkylnorephedrines catalyze the enantioselective alkylation of various pyrazole-4-carbaldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazolylalkanols with up to 95% e.e. were obtained.

AB - (1S,2R)-N,N-Dialkylnorephedrines catalyze the enantioselective alkylation of various pyrazole-4-carbaldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazolylalkanols with up to 95% e.e. were obtained.

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M3 - Article

AN - SCOPUS:0034141824

VL - 53

SP - 381

EP - 386

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

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