Catalytic asymmetric synthesis of α,β-disubstituted α,γ-diaminophosphonic acid precursors by michael addition of α-substituted nitrophosphonates to nitroolefins

Chandra Bhushan Tripathi, Satavisha Kayal, Santanu Mukherjee

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Michael additions of α-substituted nitrophosphonates to various nitroolefins are shown to proceed with high diastereo- and enantioselectivity when catalyzed by a quinine-derived thiourea-tertiary amine bifunctional catalyst and generate α,γ-diaminophosphonic acid precursors with contiguous quaternary and tertiary stereocenters.

Original languageEnglish
Pages (from-to)3296-3299
Number of pages4
JournalOrganic letters
Volume14
Issue number13
DOIs
Publication statusPublished - 2012 Jul 6
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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