Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia

H. Ichikawa, S. Gouty, J. Regalia, C. J. Helke, T. Sugimoto

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Immunohistochemistry for Ca2+/calmodulin-dependent protein kinase II (CaMKII) was performed on the rat cranial sensory ganglia. More than one half of neurons was immunoreactive for the enzyme in the trigeminal (60%) , jugular (70%), petrosal (55%) and nodose ganglia (63%). These neurons were mainly small to medium-sized. The co-expression study demonstrated that one half of CaMKII-immunoreactive (ir) neurons was also immunoreactive for calcitonin gene-related peptide (CGRP) or the vanilloid receptor subtype 1 (VR1) in the trigeminal, jugular and petrosal ganglia. In the nodose ganglion, CaMKII-ir neurons were mostly devoid of CGRP-immunoreactivity (ir) (8.2%) whereas the co-expression with VR1-ir was common among such neurons (72%). In the facial skin, nasal mucosa and palate, the epithelium and taste bud were innervated by CaMKII-ir nerve fibers. In addition, the retrograde tracing study demonstrated that 39.6% and 44.8% of trigeminal neurons which were retrogradely traced with fluorogold from the facial skin and nasal mucosa exhibited CaMKII-ir. Forty-six percent of petrosal neurons which innervated the soft palate were immunoreactive for the enzyme.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalBrain research
Volume1005
Issue number1-2
DOIs
Publication statusPublished - 2004 Apr 16

Keywords

  • Ca/calmodulin-dependent protein kinase II
  • Calcitonin gene-related peptide
  • Glossopharyngeal and vagal sensory ganglia
  • Immunohistochemistry
  • Sensory systems
  • Somatic and visceral afferents
  • The vanilloid receptor subtype 1
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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