Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies

T. Iwatsubo, I. Nakano, Koji Fukunaga, E. Miyamoto

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is one of the predominant protein kinases in the brain. We found that CaM kinase II immunoreactivity was concentrated in the peripheral halos of Lewy bodies (LBs) in Parkinson's disease and Lewy body-like hyaline inclusions (LBHIs) in amyotrophic lateral sclerosis. An immunoelectron microscopic examination of LBs revealed that the filaments at the periphery of LBs were decorated with immunopositive deposits. Since CaM kinase II has a broad substrate specificity and can phosphorylate neurofilaments and other cytoskeletal proteins, it may play some role in the formation of LBs and LBHIs through the aberrant phosphorylation of the cytoskeletal elements in these inclusions.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalActa neuropathologica
Volume82
Issue number3
DOIs
Publication statusPublished - 1991 Aug 1
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Ca/calmodulin-dependent protein kinase II
  • Lewy body
  • Lewy body-like hyaline inclusion
  • Parkinson's disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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