Ca2+-induced excess capacitance fluctuation studied by phase-sensitive detection method in exocrine pancreatic acinar cells

Yoshio Maruyama

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A phase-sensitive detection method in combination with whole-cell voltage-clamp was applied to exocrine pancreatic acinar cells from rat. The results have shown that cell-aialysis with a solution containing 5×10-7 M Ca2+ induces stp-wise changes in cell capacitance. The size distribution of increasing and decreasing capacitance steps is compatible with the idea that these capacitance steps are the results of individual granular fusion and retrieval events. This method may enable experiments studying the exo-and endo-cytotic mechanisms in morphologically polarized secretory cells.

Original languageEnglish
Pages (from-to)561-563
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume407
Issue number5
DOIs
Publication statusPublished - 1986 Nov 1

Keywords

  • Calcium
  • Capacitance fluctuation
  • Exocrine pancreas

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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