Caspase signaling in animal development

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

The caspases are a family of cysteine proteases that function as central regulators of cell death. Recent investigations in Caenorhabditis elegans, Drosophila, and mice indicate that caspases are essential not only in controlling the number of cells involved in sculpting or deleting structures in developing animals, but also in dynamic cell processes such as cell-fate determination, compensatory proliferation of neighboring cells, and actin cytoskeleton reorganization, in a non-apoptotic context during development. This review focuses primarily on caspase functions involving their enzymatic activity.

Original languageEnglish
Pages (from-to)137-148
Number of pages12
JournalDevelopment Growth and Differentiation
Volume53
Issue number2
DOIs
Publication statusPublished - 2011 Feb

Keywords

  • Apoptosis
  • Caspase signaling
  • Cell differentiation
  • Cell migration and shaping
  • Cell proliferation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Caspase signaling in animal development'. Together they form a unique fingerprint.

  • Cite this