Case Report: Adrenal Oncocytoma Associated with Markedly Increased FDG Uptake and Immunohistochemically Positive for GLUT1

Naomi Sato, Yasuhiro Nakamura, Kentaro Takanami, Yoshikiyo Ono, Kei Omata, Ryo Morimoto, Fumitoshi Satoh, Kazue Ise, Shigeyuki Yamada, Atsuko Kasajima, Fumiyoshi Fujishima, Mika Watanabe, Yoichi Arai, Hironobu Sasano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Usually, benign tumors are not associated with an increased F-18 fluorodeoxyglucose (F-18 FDG) uptake on positron emission tomography (PET), although some exceptions have been reported in adrenal neoplasms. We present a rare case of adrenocortical oncocytoma associated with markedly increased FDG uptake, demonstrating a maximum standardized uptake value of 46.8. Histological examination demonstrated diffuse proliferation of tumor cells with eosinophilic and granular cytoplasm that were diffusely immunopositive for mitochondria and glucose transport protein 1, with focal and weak immunopositivity for 3β-hydroxysteroid dehydrogenase. Ultrastructural examination also revealed abundant mitochondria in the tumor cells. The tumor was diagnosed as adrenocortical oncocytoma and was considered benign according to Lin-Weiss-Bisceglia criteria. Diagnosis of adrenocortical oncocytoma can pose difficulties during both preoperative radiological and postoperative histopathological investigations.

Original languageEnglish
Pages (from-to)410-415
Number of pages6
JournalEndocrine Pathology
Volume25
Issue number4
DOIs
Publication statusPublished - 2014 Nov 21

Keywords

  • Adrenal gland
  • FDG-PET
  • GLUT1
  • Oncocytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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