Carotid magnetic resonance imaging - A window to study atherosclerosis and identify high-risk plaques

Minako Oikawa, Hideki Ota, Norihide Takaya, Zach Miller, Thomas S. Hatsukami, Chun Yuan

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Despite recent advances in the understanding and etiology of cardiovascular disease, it remains the leading cause of morbidity and mortality worldwide. A great deal of research has been dedicated to investigating and identifying plaque instability: the so-called "vulnerable plaque". A reliable, in vivo, imaging method capable of identifying plaque characteristics associated with high-risk plaque will be immensely useful for evaluating plaque status and predicting future events. With excellent soft-tissue contrast and resolution, magnetic resonance imaging (MRI) has the ability to visualize features of vulnerable plaques, as well as perform longitudinal studies on the etiology, progression, and regression of atherosclerotic plaque. This review will cover the current state-of-the-art and new developments in carotid MRI to characterize atherosclerosis and its use in clinical diagnoses and longitudinal studies to understand mechanisms of lesion progression and regression.

Original languageEnglish
Pages (from-to)1765-1773
Number of pages9
JournalCirculation Journal
Volume73
Issue number10
DOIs
Publication statusPublished - 2009 Oct
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cardiovascular diseases
  • Carotid arteries
  • Imaging
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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