CARDIOVASCULAR AND RENAL PROTECTIVE EFFECTS OF LOSARTAN IN SPONTANEOUSLY HYPERTENSIVE RATS WITH DIABETES MELLITUS

Masahiro Kohzuki, Minoru Yasujima, Ping Fu Liu, Katsuya Obara, Masayuki Kanazawa, Kazunori Yoshida, Takao Saito, Tokutaro Sato, Keishi Abe

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15 Citations (Scopus)

Abstract

1. Cardiovascular and renal benefits of a specific angiotensin II (AII) receptor antagonist, losartan (LOS), were assessed in diabetic rats with renal impairment. 2. Uninephrectomized SHR made diabetic by streptozotocin administration were given LOS (5 mg/kg per day, i.p.) alone, captopril (CAP) (50 mg/kg per day, i.p.) alone, or a combination of CAP and LOS via osmotic minipumps for 8 weeks. 3. Both CAP alone and LOS alone completely blocked the development of hypertension in diabetic SHR in the same manner. CAP + LOS did not enhance the antihypertensive effects of LOS alone or CAP alone. 4. CAP+LOS, LOS alone and CAP alone significantly decreased urinary protein excretion and serum creatinine to the same extent. 5. These results indicate that both LOS and CAP exert antihypertensive and renoprotective effects in this model: these actions are mainly through inhibition of AII production.

Original languageEnglish
Pages (from-to)S366-S367
JournalClinical and Experimental Pharmacology and Physiology
Volume22
DOIs
Publication statusPublished - 1995 Nov

Keywords

  • captopril
  • cardiomegaly
  • proteinuria
  • spontaneously hypertensive rat

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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