[Cardio-renal interactions].

Sadayoshi Ito

Research output: Contribution to journalReview article

Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in pathophysiology of kidney and cardiovascular disease, and their interactions. Clinical studies have demonstrated that RAAS inhibition reduces cardiovascular and renal events, particularly in patients with renal dysfunction. It may be assumed that impairment of renal function induces various injurious substances such as inflammation and oxidative molecules, which may activate RAAS, and RAAS, in turn, enhances inflammations and oxidative stress. Studies have shown that indices of renal protection, such as reductions of albuminuria, are closely associated with cardiovascular protection. In addition, decrements of renal function are also associated with worse prognosis. Inhibitors of RAAS decrease urinary albumin excretion but also reduce GFR. From the clinical point of view, the most appropriate antihypertensive regime would be the one that reduces albuminuria but maintain GFR.

Original languageEnglish
Pages (from-to)1562-1570
Number of pages9
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number9
Publication statusPublished - 2012 Sep

ASJC Scopus subject areas

  • Medicine(all)

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