Cardio-ankle vascular index in heterozygous familial hypercholesterolemia

Vladimir Soska, Petr Dobsak, Ladislav Dusek, Kohji Shirai, Jiri Jarkovsky, Marie Novakova, Petr Brhel, Jana Stastna, Lenka Fajkusova, Tomas Freiberger, Tomoyuki Yambe

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. Methods: 82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9±14.9 years, were examined. CAVI was measured using the system VaSera® 1500. Results: CAVI in FH patients was significantly higher (8.0 ± 1.4) than in healthy subjects (7.5± 1.3) p = 0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p = 0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7). Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls.

Original languageEnglish
Pages (from-to)453-461
Number of pages9
JournalJournal of atherosclerosis and thrombosis
Volume19
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • Atherosclerosis
  • Cardio-ankle vascular index
  • Ezetimibe
  • Familial hypercholesterolemia
  • Statins

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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