Abstract
A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. This histological discrepancy was confirmed by assessment of the expression of Ki-67 antigen in these tumor specimens and comparison with five typical benign mixed tumors. Cranial metastasis of a histologically benign mixed tumor is extremely rare, and a carcinomatous change in the metastatic tumor is apparently unique.
Original language | English |
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Pages (from-to) | 546-550 |
Number of pages | 5 |
Journal | Neurologia medico-chirurgica |
Volume | 37 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1997 Jul |
Externally published | Yes |
Keywords
- Cranial metastasis
- Ki-67
- Metastasizing mixed tumor
- Pleomorphic adenoma
- Skull tumor
ASJC Scopus subject areas
- Surgery
- Clinical Neurology