Carcinomatous change in the cranial metastasis from a metastasizing mixed tumor of the salivary gland -Case report-

Miki Fujimura, Takayuki Sugawara, Hirobumi Seki, Yasunari Otawara, Tsutomu Sakuma, Yoshishige Nakano, Takashi Yoshimoto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. This histological discrepancy was confirmed by assessment of the expression of Ki-67 antigen in these tumor specimens and comparison with five typical benign mixed tumors. Cranial metastasis of a histologically benign mixed tumor is extremely rare, and a carcinomatous change in the metastatic tumor is apparently unique.

Original languageEnglish
Pages (from-to)546-550
Number of pages5
JournalNeurologia medico-chirurgica
Volume37
Issue number7
DOIs
Publication statusPublished - 1997 Jul

Keywords

  • Cranial metastasis
  • Ki-67
  • Metastasizing mixed tumor
  • Pleomorphic adenoma
  • Skull tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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