Carcinoma in situ detected by contralateral testicular biopsy of 55 germ cell tumor patients

Satoru Kanto, Masayoshi Hiramatsu, Akira Takeuchi, Chikara Ohyama, Makoto Sato, Seiichi Saito, Atsushi Fukuzaki, Mareyuki Endo, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


(Purpose) We performed contra-lateral testicular biopsies in 55 testicular tumor patients when high orchiectomy was performed. In these cases, two cases developed invasive testicular tumor later although the biopsies had not revealed testicular CIS. Then we re-examined the sensitivity of biopsies and judged if our results are contradictory against Skakkebaek's theory. (Patients and Methods) The paraffin blocks of two cases who later developed testicular tumor were sliced again and re-examined by H/E staining and immunostaining with PLAP antibody (clone No. 8A9). The other 53 H/E samples were re-examined and the result of the contra-lateral testis was re-searched in the case that CIS was detected in the specimen. (Results) CIS was detected in one of the two cases who later developed contra-lateral testicular tumor and another case among the other 53 cases. We could not reveal the result of the testis of case No. 3 because of the patient's disappearance. CIS existed 3.6% (2/55) and two cases were found to have been false negative. (Conclusion) It is important for both urologists and pathologists to know well about testicular CIS and to perform biopsy according to Skakkebaek's guidance for raising the sensitivity to detect testicular CIS.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalJapanese Journal of Urology
Issue number1
Publication statusPublished - 2004 Jan


  • Biopsy
  • CIS
  • Testicular tumor

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Carcinoma in situ detected by contralateral testicular biopsy of 55 germ cell tumor patients'. Together they form a unique fingerprint.

Cite this