TY - JOUR
T1 - Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia
AU - Miyazaki, Toshiki
AU - Anan, Shota
AU - Ishida, Eiichi
AU - Kawashita, Masakazu
N1 - Funding Information:
Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas, ‘‘Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control’’ (No. 2206) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT).
PY - 2013/5
Y1 - 2013/5
N2 - Recently, organic-inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20-30 lm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol-gel process was also investigated. The obtained hollow microspheres contained particles of size 20-30 lm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.
AB - Recently, organic-inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20-30 lm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol-gel process was also investigated. The obtained hollow microspheres contained particles of size 20-30 lm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.
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U2 - 10.1007/s10856-013-4874-9
DO - 10.1007/s10856-013-4874-9
M3 - Article
C2 - 23371771
AN - SCOPUS:84891646835
VL - 24
SP - 1125
EP - 1129
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 5
ER -
