Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia

Toshiki Miyazaki, Shota Anan, Eiichi Ishida, Masakazu Kawashita

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Recently, organic-inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20-30 lm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol-gel process was also investigated. The obtained hollow microspheres contained particles of size 20-30 lm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.

Original languageEnglish
Pages (from-to)1125-1129
Number of pages5
JournalJournal of Materials Science: Materials in Medicine
Volume24
Issue number5
DOIs
Publication statusPublished - 2013 May 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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