Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor

Yasufumi Sato, Michinori Waki, Motonori Ohno, Michihiko Kuwano, Toshiie Sakata

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).

Original languageEnglish
Pages (from-to)485-488
Number of pages4
JournalJapanese Journal of Cancer Research
Volume84
Issue number5
DOIs
Publication statusPublished - 1993 May
Externally publishedYes

Keywords

  • Basic fibroblast growth factor
  • Heparin‐binding domain
  • Platelet factor 4
  • Receptor binding

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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