Carbonylation Reaction of Aryl Halides on a Polymer Support Using In Situ-Generated Carbon Monoxide without the Assistance of Microwaves

Kazuo Yamazaki, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Palladium-catalyzed carbonylation, which was based on a ligand exchange reaction, efficiently converted immobilized aryl halides to amides under mild reaction conditions using molybdenum hexacarbonyl [Mo(CO)6] as the carbon monoxide source. The method easily operates without irradiating with microwaves and yields a wide range of highly pure amides after cleaving from the resin. The method could also be applied to the carbonylation of immobilized amines with aryl halides and to construct heterocyclic systems via a carbonylative cyclization.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJournal of Combinatorial Chemistry
Volume6
Issue number1
DOIs
Publication statusPublished - 2004 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)

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