Cancer predisposition caused by elevated mitotic recombination Bloom mice

Guangbin Luo, Irma M. Santoro, Lisa D. McDaniel, Ichiko Nishijima, Michael Mills, Hagop Youssoufian, Hannes Vogel, Roger A. Schultz, Allan Bradley

Research output: Contribution to journalArticlepeer-review

312 Citations (Scopus)

Abstract

Bloom syndrome is a disorder associated with genomic instability that causes affected people to be prone to cancer. Bloom cell lines show increased sister chromatid exchange, yet are proficient in the repair of various DNA lesions. The underlying cause of this disease are mutations in a gene encoding a RECQ DNA helicase. Using embryonic stem cell technology, we have generated viable Bloom mice that are prone to a wide variety of cancers. Cell lines from these mice show elevations in the rates of mitotic recombination. We demonstrate that the increased rate of loss of heterozygosity (LOH) resulting from mitotic recombination in vivo constitutes the underlying mechanism causing tumour susceptibility in these mice.

Original languageEnglish
Pages (from-to)424-429
Number of pages6
JournalNature Genetics
Volume26
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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