Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)

Yuji Shimogonya, Takuji Ishikawa, Yohsuke Imai, Noriaki Matsuki, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
JournalJournal of Biomechanics
Volume42
Issue number4
DOIs
Publication statusPublished - 2009 Mar 11

Keywords

  • Cerebral aneurysm
  • Computational fluid dynamics
  • Hemodynamics
  • Temporal fluctuation
  • Wall shear stress gradient

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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