TY - JOUR
T1 - Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)
AU - Shimogonya, Yuji
AU - Ishikawa, Takuji
AU - Imai, Yohsuke
AU - Matsuki, Noriaki
AU - Yamaguchi, Takami
N1 - Funding Information:
We thank the VISC06 committee and Dr. Makoto Ohta of the Institute of Fluid Science, Tohoku University, for providing the arterial geometry data through the VISC06 project. This study was supported in part by a Research Fellowship for Young Scientists by the Japan Society for the Promotion of Science (JSPS, No. 1955081). The authors also received support from a Grant-in-Aid for Scientific Research (S) by the JSPS (No. 19100008) and the Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”.
PY - 2009/3/11
Y1 - 2009/3/11
N2 - We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms.
AB - We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms.
KW - Cerebral aneurysm
KW - Computational fluid dynamics
KW - Hemodynamics
KW - Temporal fluctuation
KW - Wall shear stress gradient
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U2 - 10.1016/j.jbiomech.2008.10.006
DO - 10.1016/j.jbiomech.2008.10.006
M3 - Article
C2 - 19195658
AN - SCOPUS:60549098596
VL - 42
SP - 550
EP - 554
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 4
ER -