Can oral cholera vaccination play a role in controlling a cholera outbreak?

Philippe Calain, Jean Paul Chaine, Eliaser Johnson, Mary Lou Hawley, Michael J. O'Leary, Hitoshi Oshitani, Claire Lise Chaignat

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% CI: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures.

Original languageEnglish
Pages (from-to)2444-2451
Number of pages8
JournalVaccine
Volume22
Issue number19
DOIs
Publication statusPublished - 2004 Jun 23
Externally publishedYes

Keywords

  • Cholera
  • Cholera vaccines
  • Micronesia

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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