Calcium phosphate-forming ability of magnetite and related materials in a solution mimicking in vivo conditions

Yasuyuki Kato, Taishi Yokoi, Euisup Shin, Ill Yong Kim, Masakazu Kawashita, Koichi Kikuta, Chikara Ohtsuki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Iron-based compounds, especially magnetite (Fe 3 O 4 ), can be a candidate of thermoseeds for hyperthermia therapy. When iron-based compounds are applied for bone tumor treatment, they should have a heat-generating property and a bone-bonding property. However, the bone-bonding property of iron-based compounds is still unclear. The bone-bonding property of materials is estimated by their bone-like apatite formation property in simulated body fluid (SBF). The method to estimate apatite forming ability of materials by utilizing SBF was introduced by Kokubo et al. We thus report fundamental research into the behavior of iron oxides and an iron oxyhydroxide namely: FeO, Fe 3 O 4 , α-Fe 2 O 3 , γ-Fe 2 O 3 , and α-FeOOH, in SBF. Calcium phosphate precipitation was found in Fe 3 O 4 and α-Fe 2 O 3 within 7 and 28 days after soaking in SBF, respectively, while FeO, γ-Fe 2 O 3 , and α-FeOOH did not. Our results indicate that Fe 3 O 4 and α-Fe 2 O 3 have a better potential bone-bonding property than FeO, γ-Fe 2 O 3 , and α-FeOOH. The induction of apatite precipitation in SBF can be attributed to the specific structure of FeOH groups on the surface of Fe 3 O 4 and α-Fe 2 O 3 .

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalJournal of Asian Ceramic Societies
Volume3
Issue number1
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • Calcium phosphate
  • Iron oxide
  • Iron oxyhydroxide
  • Simulated body fluid

ASJC Scopus subject areas

  • Ceramics and Composites

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