Calcium concentration in cochlear endolymph after vestibular labyrinth injury

Ryoukichi Ikeda, Kazuhiro Nakaya, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The endolymphatic calcium concentration [Ca2+] is essential for acoustic transduction. This study investigated the changes in cochlear function caused by vestibular labyrinth destruction in the acute phase by measurement of the endocochlear potential and endolymphatic [Ca2+]. Hartley guinea pigs underwent lateral semicircular canal transection with suctioning of the perilymph, ampullectomy, or destruction of the lateral part of the vestibule. The endocochlear potential and endolymphatic [Ca2+] showed mild change after lateral semicircular canal transection with suctioning or ampullectomy. However, the endocochlear potential decreased drastically and permanently, and the endolymphatic [Ca2+] elevated suddenly but finally normalized after vestibulotomy. Elevated endolymphatic [Ca2+] is important in the disturbance of the mechanism of cochlear function caused by vestibular labyrinth destruction.

Original languageEnglish
Pages (from-to)651-655
Number of pages5
JournalNeuroReport
Volume21
Issue number9
DOIs
Publication statusPublished - 2010 Jun 23

Keywords

  • Ampullectomy
  • Calcium
  • Endocochlear potential
  • Lateral semicircular canal
  • Vestibulotomy

ASJC Scopus subject areas

  • Neuroscience(all)

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