Calcitonin gene-related peptide-like immunoreactivities in pheochromocytomas

Toraichi Mouri, Kazuhiro Takahashi, Masahiko Sone, Osamu Murakami, Makoto Ohneda, Keiichi Itoi, Yutaka Imai, Kaoru Yoshinaga, Nobuaki Sasano

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Calcitonin gene-related peptide (CGRP) is reported to exist in high concentrations in plasma and tumor tissues of medullary thyroid carcinomas. CGRP-like immunoreactivity (LI) in tumor tissues of pheochromocytomas was investigated by radioimmunoassay. CGRP-LI in 9 pheochromocytomas ranged from 0.50 to 1240 ng/g wet tissue. Sephadex G-50 column chromatography revealed that most of CGRP-LI in tumor extracts was eluted in an identical position to synthetic human CGRP. Reverse-phase high pressure liquid chromatography revealed that CGRP-LI in tumor extracts was eluted in an identical position to synthetic human CGRP and in a more hydrophobic position. These results indicate that high concentrations of CGRP-LI also exist in tumor tissues of pheochromocytomas.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalPeptides
Volume10
Issue number1
DOIs
Publication statusPublished - 1989

Keywords

  • Calcitonin gene-related peptide (CGRP)
  • Pheochromocytoma
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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