TY - JOUR
T1 - C-reactive protein and peripheral artery disease among Japanese elderly
T2 - The Tsurugaya project
AU - Hozawa, Atsushi
AU - Ohmori, Kaori
AU - Kuriyama, Shinichi
AU - Shimazu, Taichi
AU - Niu, Kaijun
AU - Watando, Aya
AU - Ebihara, Satoru
AU - Matsui, Toshifumi
AU - Ichiki, Masataka
AU - Nagatomi, Ryoichi
AU - Sasaki, Hidetada
AU - Tsuji, Ichiro
PY - 2004/12
Y1 - 2004/12
N2 - We investigated the cross-sectional relationship between ankle brachial index and cardiovascular disease risk factors, including C-reactive protein (CRP), among Japanese elderly, a topic which has had little prior epidemiologic study. Our study population comprised 946 subjects aged at least 70 years in whom both CRP and ankle brachial index were measured. The participants were classified into a low (ankle brachial index<0.9) and normal ankle brachial index group. We found that current smoking, high-density lipoprotein cholesterol < 40 mg/dl, a low body mass index (continuous variable), hypertension, diabetes and statin use were all significantly related to a lower ankle brachial index. Higher log-transformed CRP level was significantly related to a lower ankle brachial index after adjustment for the cardiovascular risk factors mentioned above (p<0.01). The odds ratios for low ankle brachial index compared to 0-1 risk factors were 5.79 (95% confidence interval [CI]: 2.99-11.20) for 2 risk factors and 17.45 (95% CI: 6.78-49.91) for 3 or more risk factors; independently of other risk factors, the odds ratio for CRP>1.0 mg/l was 2.10 (95% CI: 1.13-3.88) compared to lower CRP values. Thus, a high level of CRP is related to a low ankle brachial index among Japanese elderly as well as Western subjects. This is the first study to report the relationship between CRP and low ankle brachial index among Japanese elderly.
AB - We investigated the cross-sectional relationship between ankle brachial index and cardiovascular disease risk factors, including C-reactive protein (CRP), among Japanese elderly, a topic which has had little prior epidemiologic study. Our study population comprised 946 subjects aged at least 70 years in whom both CRP and ankle brachial index were measured. The participants were classified into a low (ankle brachial index<0.9) and normal ankle brachial index group. We found that current smoking, high-density lipoprotein cholesterol < 40 mg/dl, a low body mass index (continuous variable), hypertension, diabetes and statin use were all significantly related to a lower ankle brachial index. Higher log-transformed CRP level was significantly related to a lower ankle brachial index after adjustment for the cardiovascular risk factors mentioned above (p<0.01). The odds ratios for low ankle brachial index compared to 0-1 risk factors were 5.79 (95% confidence interval [CI]: 2.99-11.20) for 2 risk factors and 17.45 (95% CI: 6.78-49.91) for 3 or more risk factors; independently of other risk factors, the odds ratio for CRP>1.0 mg/l was 2.10 (95% CI: 1.13-3.88) compared to lower CRP values. Thus, a high level of CRP is related to a low ankle brachial index among Japanese elderly as well as Western subjects. This is the first study to report the relationship between CRP and low ankle brachial index among Japanese elderly.
KW - Ankle brachial index
KW - C-reactive protein
KW - Cardiovascular risk factors
KW - Elderly
KW - Japanese
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U2 - 10.1291/hypres.27.955
DO - 10.1291/hypres.27.955
M3 - Article
C2 - 15894836
AN - SCOPUS:20144370683
VL - 27
SP - 955
EP - 961
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 12
ER -