C. elegans as a model system to study the function of the COG complex in animal development

Yukihiko Kubota, Kiyoji Nishiwaki

    Research output: Contribution to journalShort surveypeer-review

    8 Citations (Scopus)

    Abstract

    The conserved oligomeric Golgi (COG) complex is an octameric protein complex associated with the Golgi apparatus and is required for proper sorting and glycosylation of Golgi resident enzymes and secreted proteins. Although COG complex function has been extensively studied at the cellular and subcellular levels, its role in animal development mostly remains unknown. Recently, mutations in the components of the COG complex were found to cause abnormal gonad morphogenesis in Caenorhabditis elegans. In C. elegans, the COG complex acts in the glycosylation of an ADAM (a disintegrin and metalloprotease) family protein, MIG-17, which directs migration of gonadal distal tip cells to lead gonad morphogenesis. This is the first link between the COG complex and the function of an ADAM protease that is directly involved in organ morphogenesis, demonstrating the potential of C. elegans as a model system to study COG function in animal development.

    Original languageEnglish
    Pages (from-to)1031-1035
    Number of pages5
    JournalBiological Chemistry
    Volume387
    Issue number8
    DOIs
    Publication statusPublished - 2006 Aug 1

    Keywords

    • ADAM protease
    • COG complex
    • Caenorhabditis elegans
    • Glycosylation
    • Golgi enzyme
    • Organogenesis

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Clinical Biochemistry

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