bZIP transcription factor RSG controls the feedback regulation of NtGA20ox1via intracellular localization and epigenetic mechanism

Jutarou Fukazawa, Masaru Nakata, Takeshi Ito, Akane Matsushita, Shinjiro Yamaguchi, Yohsuke Takahashi

    Research output: Contribution to journalReview articlepeer-review

    13 Citations (Scopus)

    Abstract

    Gibberellins (GAs) are phytohormones that regulate growth and development throughout the life cycle of plants. Negative feedback contributes to homeostasis of GA levels. DeLLA proteins are involved in this process. Since DeLLA proteins do not have apparent DnA binding motifs, other DnA binding proteins might act as a mediator downstream of DeLLA proteins in the GA feedback regulation. in this review, we highlight the mechanisms of GA feedback regulation, specifically the differential regulation of GA 20-oxidase (GA20ox) and GA 3-oxidase (GA3ox) by transcription factors. RSG (RePReSSiOn OF SHOOT GROwTH) is a tobacco (Nicotiana tabacum) transcriptional activator with a basic leucine zipper domain that controls the levels of endogenous GAs through the regulation of GA biosynthesis genes. Recently we reported that RSG not only regulates the expression of ent-kaurene oxidase gene but is also involved in the negative feedback of NtGA20ox1 by GAs. RSG plays a role in the homeostasis of GAs through direct binding to the NtGA20ox1 promoter triggered by a decrease in GA levels in the cell. Furthermore, decreases in GA levels promote modifications of active histone marks on the NtGA20ox1 promoter. We have developed a hypothetical model to explain how RSG regulates dual target genes via epigenetic regulation.

    Original languageEnglish
    JournalPlant Signaling and Behavior
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 2011 Jan 1

    Keywords

    • Feedback regulation
    • GA 20-oxidase
    • Gibberellin biosynthesis
    • Histone modification
    • REPRESSION OF SHOOT GROWTH
    • Signaling
    • Transcription factor

    ASJC Scopus subject areas

    • Plant Science

    Fingerprint Dive into the research topics of 'bZIP transcription factor RSG controls the feedback regulation of NtGA20ox1via intracellular localization and epigenetic mechanism'. Together they form a unique fingerprint.

    Cite this