TY - JOUR
T1 - bZIP transcription factor RSG controls the feedback regulation of NtGA20ox1via intracellular localization and epigenetic mechanism
AU - Fukazawa, Jutarou
AU - Nakata, Masaru
AU - Ito, Takeshi
AU - Matsushita, Akane
AU - Yamaguchi, Shinjiro
AU - Takahashi, Yohsuke
PY - 2011/1
Y1 - 2011/1
N2 - Gibberellins (GAs) are phytohormones that regulate growth and development throughout the life cycle of plants. Negative feedback contributes to homeostasis of GA levels. DeLLA proteins are involved in this process. Since DeLLA proteins do not have apparent DnA binding motifs, other DnA binding proteins might act as a mediator downstream of DeLLA proteins in the GA feedback regulation. in this review, we highlight the mechanisms of GA feedback regulation, specifically the differential regulation of GA 20-oxidase (GA20ox) and GA 3-oxidase (GA3ox) by transcription factors. RSG (RePReSSiOn OF SHOOT GROwTH) is a tobacco (Nicotiana tabacum) transcriptional activator with a basic leucine zipper domain that controls the levels of endogenous GAs through the regulation of GA biosynthesis genes. Recently we reported that RSG not only regulates the expression of ent-kaurene oxidase gene but is also involved in the negative feedback of NtGA20ox1 by GAs. RSG plays a role in the homeostasis of GAs through direct binding to the NtGA20ox1 promoter triggered by a decrease in GA levels in the cell. Furthermore, decreases in GA levels promote modifications of active histone marks on the NtGA20ox1 promoter. We have developed a hypothetical model to explain how RSG regulates dual target genes via epigenetic regulation.
AB - Gibberellins (GAs) are phytohormones that regulate growth and development throughout the life cycle of plants. Negative feedback contributes to homeostasis of GA levels. DeLLA proteins are involved in this process. Since DeLLA proteins do not have apparent DnA binding motifs, other DnA binding proteins might act as a mediator downstream of DeLLA proteins in the GA feedback regulation. in this review, we highlight the mechanisms of GA feedback regulation, specifically the differential regulation of GA 20-oxidase (GA20ox) and GA 3-oxidase (GA3ox) by transcription factors. RSG (RePReSSiOn OF SHOOT GROwTH) is a tobacco (Nicotiana tabacum) transcriptional activator with a basic leucine zipper domain that controls the levels of endogenous GAs through the regulation of GA biosynthesis genes. Recently we reported that RSG not only regulates the expression of ent-kaurene oxidase gene but is also involved in the negative feedback of NtGA20ox1 by GAs. RSG plays a role in the homeostasis of GAs through direct binding to the NtGA20ox1 promoter triggered by a decrease in GA levels in the cell. Furthermore, decreases in GA levels promote modifications of active histone marks on the NtGA20ox1 promoter. We have developed a hypothetical model to explain how RSG regulates dual target genes via epigenetic regulation.
KW - Feedback regulation
KW - GA 20-oxidase
KW - Gibberellin biosynthesis
KW - Histone modification
KW - REPRESSION OF SHOOT GROWTH
KW - Signaling
KW - Transcription factor
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U2 - 10.4161/psb.6.1.14114
DO - 10.4161/psb.6.1.14114
M3 - Review article
C2 - 21248488
AN - SCOPUS:79956215977
VL - 6
JO - Plant Signaling and Behavior
JF - Plant Signaling and Behavior
SN - 1559-2316
IS - 1
ER -