Burn-induced subepicardial injury in frog heart: A simple model mimicking ST segment changes in ischemic heart disease

Itsuro Kazama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

To mimic ischemic heart disease in humans, several animal models have been created, mainly in rodents by surgically ligating their coronary arteries. In the present study, by simply inducing burn injuries on the bullfrog heart, we reproduced abnormal ST segment changes in the electrocardiogram (ECG), mimicking those observed in ischemic heart disease, such as acute myocardial infarction and angina pectoris. The “currents of injury” created by a voltage gradient between the intact and damaged areas of the myocardium, negatively deflected the ECG vector during the diastolic phase, making the ST segment appear elevated during the systolic phase. This frog model of heart injury would be suitable to explain the mechanisms of ST segment changes observed in ischemic heart disease.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalJournal of Veterinary Medical Science
Volume78
Issue number2
DOIs
Publication statusPublished - 2016 Feb

Keywords

  • Bullfrog heart
  • Burn injury
  • Currents of injury
  • Ischemic heart disease
  • ST segment change

ASJC Scopus subject areas

  • veterinary(all)

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